If the property is not your primary residence, it is not eligible to be licensed as a short-term rental. To rent such a property on a short-term basis, you need to get a lodging facility license. See the licensing page for more information and to check eligibility requirements. Lodging facilities are restricted to certain zone districts. A change of building occupancy classification could be required and will likely have construction impacts, including but not limited to requirements for a fire sprinkler system, a fire alarm/detection system, exit signage, and accessibility upgrades. Visit for change of occupancy guidelines.
A change in zoning use from residential to lodging could also be required. A zoning permit is required to change or establish a new zoning use. A change in use to lodging (whether it's one unit in a building changing use, or an entire building changing use) is allowed under the Denver Zoning Code as long as the property is in a zone district that allows lodging accommodations as a zoning use. Visit for more information on the permitting requirements for a change in zoning use, or to determine your property's zone district.